Browsing NIVA Open Access Archive by Author "Hultman, Maria Thérése"
Now showing items 1-8 of 8
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Characterizing combined effects of antiestrogenic chemicals on vitellogenin production in rainbow trout (Oncorhynchus mykiss) hepatocytes
Hultman, Maria Thérése; Petersen, Karina; Tollefsen, Knut Erik (Journal article; Peer reviewed, 2017)Fish are exposed to a complex mixture of endocrine disrupting compounds (EDC), some of which display antiestrogenic activity leading to suppression of estrogen receptor (ER)- mediated reproductive processes. Although the ... -
Characterizing cytotoxic and estrogenic activity of Arctic char tissue extracts in primary Arctic char hepatocytes
Petersen, Karina; Hultman, Maria Thérése; Bytingsvik, Jenny; Harju, Mikael; Evenset, Anita; Tollefsen, Knut Erik (Journal article; Peer reviewed, 2017)Contaminants from various anthropogenic activities are detected in the Arctic due to long-range atmospheric transport, ocean currents, and living organisms such as migrating fish or seabirds. Although levels of persistent ... -
Evaluation of the sensitivity, responsiveness and reproducibility of primary rainbow trout hepatocyte vitellogenin expression as a screening assay for estrogen mimics
Hultman, Maria Thérése; Rundberget, Thomas; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2014)Vitellogenin (Vtg) induction in primary fish hepatocytes has been proposed as an in vitro screening assay for ER agonists and antagonists, but has not yet been used extensively as a high-throughput screening tool due to ... -
Hurtigmetoder for online deteksjon av mikrobiell forurensning i vann
Wennberg, Aina Charlotte; Hultman, Maria Thérése (NIVA-rapport;7288, Research report, 2018)Dagens krav til overvåking av hygienisk vannkvalitet for drikkevann og badevann inkluderer kun dyrkingsmetoder som tar ett til tre døgn å analysere. For bedre å kunne vurdere og håndtere hygienisk risiko er det et ønske ... -
Integrated biomarker assessment of the effects of tailing discharges from an iron ore mine using blue mussels (Mytilus spp.)
Brooks, Steven; Harman, Christopher Peter; Hultman, Maria Thérése; Berge, John A (Journal article; Peer reviewed, 2015)The blue mussel (Mytilus spp.) has been used to assess the potential biological effects of the discharge effluent from the Sydvaranger mine, which releases its tailings into Bøk fjord at Kirkenes in the north of Norway. ... -
Performance of Three-Dimensional Rainbow Trout (Oncorhynchus mykiss) Hepatocyte Spheroids for Evaluating Biotransformation of Pyrene
Hultman, Maria Thérése; Løken, Katharina Bjarnar; Grung, Merete; Reid, Malcolm J; Lillicrap, Adam (Journal article; Peer reviewed, 2019)The aquatic bioconcentration of a chemical is typically determined using conventional fish tests. To foster the approach of alternatives to animal testing, a combination of computational models and in vitro substrate ... -
Repeatability and reproducibility of the RTgill-W1 cell line assay for predicting fish acute toxicity
Fischer, Melanie; Belanger, Scott E.; Berckmans, Pascale; Bernhard, Mary J.; Bláha, Ludek; Coman Schmid, Diana E.; Dyer, Scott D.; Haupt, Tina; Hermens, Joop L.M.; Hultman, Maria Thérése; Laue, Heike; Lillicrap, Adam David; Mlnaříková, Marie; Natsch, Andreas; Novák, Jirí; Sinnige, Theo L.; Tollefsen, Knut-Erik; Niederhäusern, Valentin von; Witters, Hilda; Zupanic, Anze; Schirmer, Kristin (Journal article; Peer reviewed, 2019)Predicting fish acute toxicity of chemicals in vitro is an attractive alternative method to the conventional approach using juvenile and adult fish. The rainbow trout (Oncorhynchus mykiss) cell line assay with RTgill-W1 ... -
Storskala utlekkingstest av bildekkrelevante forurensningsstoffer fra Huggenes støyvoll (E6, Råde)
Meland, Sondre; Hultman, Maria Thérése; Georgantzopoulou, Anastasia; Petersen, Karina; Brandt, Uta; Kringstad, Alfhild; Rundberget, Jan Thomas; Grung, Merete (Peer reviewed; Journal article, 2020)Brukte bildekk utgjør et stort avfallsproblem. Dekk skal derfor gjenvinnes i form av ombruk, materialgjenvinning eller energiutnyttelse. Tidlig 2000-tall testet Statens vegvesen bruk av kasserte bildekk som byggemateriale ...