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dc.contributor.authorRyu, Yeonsuk
dc.contributor.authorGracia-Lor, Emma
dc.contributor.authorBade, Richard
dc.contributor.authorBaz-Lomba, J A
dc.contributor.authorBramness, Jørgen G
dc.contributor.authorCastiglioni, Sara
dc.contributor.authorCastrignanò, Erika
dc.contributor.authorCausanilles, Ana
dc.contributor.authorCovaci, Adrian
dc.contributor.authorDe Voogt, Pim
dc.contributor.authorHernandez, Felix
dc.contributor.authorKasprzyk-Hordern, Barbara
dc.contributor.authorKinyua, Juliet
dc.contributor.authorMcCall, Ann-Kathrin
dc.contributor.authorOrt, Christoph
dc.contributor.authorPlosz, Benedek G
dc.contributor.authorRamin, Pedram
dc.contributor.authorRousis, Nikolaos I.
dc.contributor.authorReid, Malcolm J
dc.contributor.authorThomas, Kevin V
dc.date.accessioned2018-08-01T08:35:06Z
dc.date.available2018-08-01T08:35:06Z
dc.date.created2017-02-23T12:23:40Z
dc.date.issued2016
dc.identifier.citationScientific Reports. 2016, 6, 7, 39055.nb_NO
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11250/2507076
dc.description.abstractWastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F2-isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F2α (8-iso-PGF2α) was analysed in raw 24 h-composite wastewater samples collected from 4 Norwegian and 7 other European cities in 2014 and 2015. Using the same samples, biomarkers of alcohol (ethyl sulfate) and tobacco (trans-3′-hydroxycotinine) use were also analysed to investigate any possible correlation between 8-iso-PGF2α and the consumption of the two drugs. The estimated per capita daily loads of 8-iso-PGF2α in the 11 cities ranged between 2.5 and 9.9 mg/day/1000 inhabitants with a population-weighted mean of 4.8 mg/day/1000 inhabitants. There were no temporal trends observed in the levels of 8-iso-PGF2α, however, spatial differences were found at the inter-city level correlating to the degree of urbanisation. The 8-iso-PGF2α mass load was found to be strongly associated with that of trans-3′-hydroxycotinine while it showed no correlation with ethyl sulfate. The present study shows the potential for 8-iso-PGF2α as a wastewater biomarker for the assessment of community public health.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleIncreased levels of the oxidative stress biomarker 8-iso-prostaglandin F2α in wastewater associated with tobacco usenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© The Author(s) 2016nb_NO
dc.source.pagenumber7nb_NO
dc.source.volume6nb_NO
dc.source.journalScientific Reportsnb_NO
dc.identifier.doi10.1038/srep39055
dc.identifier.cristin1453394
dc.relation.projectEC/FP7/317205nb_NO
dc.relation.projectAPOSTD/2015: Programa VALi + dnb_NO
cristin.unitcode7464,30,21,0
cristin.unitcode7464,20,13,0
cristin.unitnameMiljøkjemi
cristin.unitnameØkotoksikologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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