dc.contributor.author | Ryu, Yeonsuk | |
dc.contributor.author | Gracia-Lor, Emma | |
dc.contributor.author | Bade, Richard | |
dc.contributor.author | Baz-Lomba, J A | |
dc.contributor.author | Bramness, Jørgen G | |
dc.contributor.author | Castiglioni, Sara | |
dc.contributor.author | Castrignanò, Erika | |
dc.contributor.author | Causanilles, Ana | |
dc.contributor.author | Covaci, Adrian | |
dc.contributor.author | De Voogt, Pim | |
dc.contributor.author | Hernandez, Felix | |
dc.contributor.author | Kasprzyk-Hordern, Barbara | |
dc.contributor.author | Kinyua, Juliet | |
dc.contributor.author | McCall, Ann-Kathrin | |
dc.contributor.author | Ort, Christoph | |
dc.contributor.author | Plosz, Benedek G | |
dc.contributor.author | Ramin, Pedram | |
dc.contributor.author | Rousis, Nikolaos I. | |
dc.contributor.author | Reid, Malcolm J | |
dc.contributor.author | Thomas, Kevin V | |
dc.date.accessioned | 2018-08-01T08:35:06Z | |
dc.date.available | 2018-08-01T08:35:06Z | |
dc.date.created | 2017-02-23T12:23:40Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Scientific Reports. 2016, 6, 7, 39055. | nb_NO |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/11250/2507076 | |
dc.description.abstract | Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F2-isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F2α (8-iso-PGF2α) was analysed in raw 24 h-composite wastewater samples collected from 4 Norwegian and 7 other European cities in 2014 and 2015. Using the same samples, biomarkers of alcohol (ethyl sulfate) and tobacco (trans-3′-hydroxycotinine) use were also analysed to investigate any possible correlation between 8-iso-PGF2α and the consumption of the two drugs. The estimated per capita daily loads of 8-iso-PGF2α in the 11 cities ranged between 2.5 and 9.9 mg/day/1000 inhabitants with a population-weighted mean of 4.8 mg/day/1000 inhabitants. There were no temporal trends observed in the levels of 8-iso-PGF2α, however, spatial differences were found at the inter-city level correlating to the degree of urbanisation. The 8-iso-PGF2α mass load was found to be strongly associated with that of trans-3′-hydroxycotinine while it showed no correlation with ethyl sulfate. The present study shows the potential for 8-iso-PGF2α as a wastewater biomarker for the assessment of community public health. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Nature Publishing Group | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F2α in wastewater associated with tobacco use | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.rights.holder | © The Author(s) 2016 | nb_NO |
dc.source.pagenumber | 7 | nb_NO |
dc.source.volume | 6 | nb_NO |
dc.source.journal | Scientific Reports | nb_NO |
dc.identifier.doi | 10.1038/srep39055 | |
dc.identifier.cristin | 1453394 | |
dc.relation.project | EC/FP7/317205 | nb_NO |
dc.relation.project | APOSTD/2015: Programa VALi + d | nb_NO |
cristin.unitcode | 7464,30,21,0 | |
cristin.unitcode | 7464,20,13,0 | |
cristin.unitname | Miljøkjemi | |
cristin.unitname | Økotoksikologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |