Blar i NIVA Open Access Archive på forfatter "Song, You"
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Hepatic transcriptomic profiling reveals early toxicological mechanisms of uranium in Atlantic salmon (Salmo salar)
Song, You; Salbu, Brit; Teien, Hans-Christian; Heier, Lene Sørlie; Rosseland, Bjørn Olav; Høgåsen, Tore; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2014) -
High-throughput analyses and Bayesian network modeling highlight novel epigenetic Adverse Outcome Pathway networks of DNA methyltransferase inhibitor mediated transgenerational effects
Song, You; Kamstra, Jorke H; Cao, Yang; Asselman, Jana; Anglès d'Auriac, Marc; Friberg, Nikolai (Peer reviewed; Journal article, 2021)A number of epigenetic modulating chemicals are known to affect multiple generations of a population from a single ancestral exposure, thus posing transgenerational hazards. The present study aimed to establish a high-throughput ... -
In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding
Evenseth, Linn M.; Kristiansen, Kurt; Song, You; Tollefsen, Knut Erik; Sylte, Ingebrigt (Journal article; Peer reviewed, 2019)Molting is an essential process in the life cycle of arthropods and is regulated by complex neuroendocrine pathways where activation of the ecdysone receptor (EcR) plays a major role. The EcR forms a non-covalent heterodimer ... -
Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development
Song, You; Xie, Li; Lee, YeonKyeong; Brede, Dag Anders; Lyne, Fern; Kassaye, Yetneberk Ayalew; Thaulow, Jens; Caldwell, Gary S.; Salbu, Brit; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2020)High energy gamma radiation is potentially hazardous to organisms, including aquatic invertebrates. Although extensively studied in a number of invertebrate species, knowledge on effects induced by gamma radiation is to a ... -
Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development
Toyota, Kenji; Watanabe, Haruna; Hirano, Masashi; Abe, Ryoko; Miyakawa, Hitoshi; Song, You; Sato, Tomomi; Miyagawa, Shinichi; Tollefsen, Knut Erik; Yamamoto, Hiroshi; Tatarazako, Norihisa; Iguchi, Taisen (Peer reviewed; Journal article, 2021)Juvenile hormone (JH) are a family of multifunctional hormones regulating larval development, molting, metamorphosis, reproduction, and phenotypic plasticity in arthropods. Based on its importance in arthropod life histories, ... -
Linking mode of action of the model respiratory and photosynthesis uncoupler 3,5-dichlorophenol to adverse outcomes in Lemna minor
Xie, Li; Gomes, Tania; Solhaug, Knut Asbjørn; Song, You; Tollefsen, Knut Erik (Journal article; Peer reviewed, 2018)Standard chemical toxicity testing guidelines using aquatic plant Lemna minor have been developed by several international standardisation organisations. Although being highly useful for regulatory purposes by focusing on ... -
Microfiber Hotspots’ Association with Ships in a Remote Port before and during Covid-19
Peng, Guyu; Mengeot, Caroline; Jiang, Chunhua; Xu, Baile; Zhong, Xin; Song, You; Zhang, Feng; Li, Daoji (Peer reviewed; Journal article, 2023)During monthly water quality monitoring of Norwegian coastal waters, the sea surface waters off Brønnøysund, a remote port in Norway, exhibited an unexpectedly high abundance of microfibers. We further conducted monitoring ... -
Modes of action and adverse effects of gamma radiation in an aquatic macrophyte Lemna minor
Xie, Li; Solhaug, Knut Asbjørn; Song, You; Brede, Dag Anders; Lind, Ole Christian; Salbu, Brit; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2019)High dose rates of ionizing radiation have been reported to cause adverse effects such as reduction in reproduction and growth, and damage to protein and lipids in primary producers. However, the relevant effects of ionizing ... -
Mortality and transcriptional effects of inorganic mercury in the marine copepod Calanus finmarchicus
Tollefsen, Knut Erik; Song, You; Høgåsen, Tore; Øverjordet, Ida Beathe; Altin, Dag; Hansen, Bjørn Henrik (Journal article; Peer reviewed, 2017)Inorganic mercury (Hg) is highly toxic to organisms including crustaceans and displays multiple toxic modes of action (MoA). The main aim of this investigation was to assess the acute and sublethal toxicity mediated by ... -
Multiomics Point of Departure (moPOD) Modeling Supports an Adverse Outcome Pathway Network for Ionizing Radiation
Song, You; Zheng, Keke; Brede, Dag Anders; Gomes, Tania; Xie, Li; Kassaye, Yetneberk Ayalew; Salbu, Brit; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2023)While adverse biological effects of acute high-dose ionizing radiation have been extensively investigated, knowledge on chronic low-dose effects is scarce. The aims of the present study were to identify hazards of low-dose ... -
New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians
Mitchell, Constance A.; Burden, Natalie; Bonnell, Mark; Hecker, Markus; Hutchinson, Thomas H.; Jagla, Magdalena; LaLone, Carlie A.; Lagadic, Laurent; Lynn, Scott G.; Shore, Bryon; Song, You; Vliet, Sara M.; Wheeler, James R.; Embry, Michelle R. (Peer reviewed; Journal article, 2023)Multiple in vivo test guidelines focusing on the estrogen, androgen, thyroid, and steroidogenesis pathways have been developed and validated for mammals, amphibians, or fish. However, these tests are resource-intensive and ... -
De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining
Song, You; Xie, Li; Lee, YeonKyeong; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2020)Ultraviolet B (UVB) radiation is a natural non-chemical stressor posing potential hazards to organisms such as planktonic crustaceans. The present study was conducted to revisit the lethal effects of UVB on crustaceans, ... -
Release of chitobiase as an indicator of potential molting disruption in juvenile Daphnia magna exposed to the ecdysone receptor agonist 20-hydroxyecdysone
Song, You; Evenseth, Linn Mari; Iguchi, Taisen; Tollefsen, Knut Erik (Journal article; Peer reviewed, 2017)During arthropod molting, the old exoskeleton is degraded and recycled by the molting fluid. Chitobiase, a major chitinolytic enzyme in the molting fluid, has been widely used as a biomarker to indicate endocrine disruption ... -
Susceptibility of polar cod (Boreogadus saida) to a model carcinogen
Lerebours, Adélaïde; Murzina, Svetlana; Song, You; Tollefsen, Knut-Erik; Benedetti, Maura; Regoli, Francesco; Rotchell, Jeanette M.; Nahrgang, Jasmine (Peer reviewed; Journal article, 2021)Studies that aim to characterise the susceptibility of the ecologically relevant and non-model fish polar cod (Boreogadus saida) to model carcinogens are required. Polar cod were exposed under laboratory conditions for six ... -
Transcriptional changes in Atlantic salmon (Salmo salar) after embryonic exposure to road salt
Tollefsen, Knut Erik; Song, You; Kleiven, Merethe; Mahrosh, Urma; Meland, Sondre; Rosseland, Bjørn Olav; Teien, Hans-Christian (Journal article; Peer reviewed, 2015)Road salt is extensively used as a deicing chemical in road maintenance during winter and has in certain areas of the world led to density stratifications in lakes and ponds, and adversely impacted aquatic organisms in the ... -
Transcriptomic analysis reveals dose-dependent modes of action of benzo(a)pyrene in polar cod (Boreogadus saida)
Song, You; Nahrgang, Jasmine; Tollefsen, Knut Erik (Journal article; Peer reviewed, 2019)Polar cod (Boreogadus saida) has been used as a model Arctic species for hazard assessment of environmental stressors such as polycyclic aromatic hydrocarbons (PAHs). However, most of the PAH studies using polar cod rely ... -
Ultraviolet B modulates gamma radiation-induced stress responses in Lemna minor at multiple levels of biological organisation
Xie, Li; Song, You; Petersen, Karina; Solhaug, Knut Asbjørn; Lind, Ole Christian; Brede, Dag Anders; Salbu, Brit; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2022)Elevated levels of ionizing and non-ionizing radiation may co-occur and pose cumulative hazards to biota. However, the combined effects and underlying toxicity mechanisms of different types of radiation in aquatic plants ... -
Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses
Scheibener, Shane; Song, You; Tollefsen, Knut-Erik; Salbu, Brit; Teien, Hans-Christian (Peer reviewed; Journal article, 2021)The importance of incorporating kinetic approaches in order to gain information on underlying physiological processes explaining species sensitivity to environmental stressors has been highlighted in recent years. Uranium ... -
Whole-Organism Transcriptomic Analysis Provides Mechanistic Insight into the Acute Toxicity of Emamectin Benzoate in Daphnia magna
Song, You; Rundberget, Thomas; Evenseth, Linn Mari; Xie, Li; Gomes, Tania; Høgåsen, Tore; Iguchi, Taisen; Tollefsen, Knut Erik (Journal article; Peer reviewed, 2016)Emamectin benzoate (EMB) is an antisea lice chemical widely used in the aquaculture that may also unintentionally affect nontarget crustaceans in the environment. Although the adverse effects of this compound are well ...