Blar i NIVA Open Access Archive på forfatter "Tollefsen, Knut-Erik"
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Knowledge graph embedding for ecotoxicological effect prediction
Myklebust, Erik Bryhn; Jimenez-Ruiz, Ernesto; Chen, Jiaoyan; Wolf, Raoul; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2019)Exploring the effects of a chemical compound on a species takes a considerable experimental effort. Appropriate methods for estimating and suggesting new effects can dramatically reduce the work needed to be done by a ... -
The MicroClimate Screen – A microscale climate exposure system for assessing the effect of CO2, temperature and UV on marine microalgae
Xie, Li; Macken, Ailbhe; Johnsen, Bjørn; Norli, Marit; Skogan, Odd Arne Segtnan; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2022)Global warming and anthropogenic activities are changing the ocean, inducing profound impacts on marine life and ecosystems from changing physical and chemical factors in and above the water column. Rising surface temperatures, ... -
Mixture effects in samples of multiple contaminants – An inter-laboratory study with manifold bioassays
Altenburger, Rolf; Scholze, Martin; Busch, Wibke; Escher, Beate; Jakobs, Gianina; Krauss, Martin; Krüger, Janet; Neale, Peta A.; Aït-Aïssa, Selim; Almeida, Ana Catarina; Seiler, Thomas-Benjamin; Brion, François; Hilscherová, Klára; Hollert, Henner; Novak, Jiri; Schlichting, Rita; Serra, Helene; Shao, Ying; Tindall, Andrew; Tollefsen, Knut-Erik; Umbuzeiro, Gisela de Aragão; Williams, Timothy D.; Kortenkamp, Andreas (Journal article; Peer reviewed, 2018)Chemicals in the environment occur in mixtures rather than as individual entities. Environmental quality monitoring thus faces the challenge to comprehensively assess a multitude of contaminants and potential adverse ... -
Modes of action and adverse effects of gamma radiation in an aquatic macrophyte Lemna minor
Xie, Li; Solhaug, Knut Asbjørn; Song, You; Brede, Dag Anders; Lind, Ole Christian; Salbu, Brit; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2019)High dose rates of ionizing radiation have been reported to cause adverse effects such as reduction in reproduction and growth, and damage to protein and lipids in primary producers. However, the relevant effects of ionizing ... -
Multiomics Point of Departure (moPOD) Modeling Supports an Adverse Outcome Pathway Network for Ionizing Radiation
Song, You; Zheng, Keke; Brede, Dag Anders; Gomes, Tania; Xie, Li; Kassaye, Yetneberk Ayalew; Salbu, Brit; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2023)While adverse biological effects of acute high-dose ionizing radiation have been extensively investigated, knowledge on chronic low-dose effects is scarce. The aims of the present study were to identify hazards of low-dose ... -
De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining
Song, You; Xie, Li; Lee, YeonKyeong; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2020)Ultraviolet B (UVB) radiation is a natural non-chemical stressor posing potential hazards to organisms such as planktonic crustaceans. The present study was conducted to revisit the lethal effects of UVB on crustaceans, ... -
Oxidative stress potential of the herbicides bifenox and metribuzin in the microalgae Chlamydomonas reinhardtii
Almeida, Ana Catarina; Gomes, Tania; Langford, Katherine; Thomas, Kevin V; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2019)The widespread presence of herbicides in the aquatic environment has raised awareness about the need to develop further in depth ecotoxicological risk assessments, more specifically on potential effects on photosynthetic ... -
Pharmaceutical pollution: Prediction of environmental concentrations from national wholesales data
Welch, Samuel Alexander Stafford; Olsen, Kristine; Nouri Sharikabad, Mohammad; Tollefsen, Knut-Erik; Grung, Merete; Moe, Solveig Jannicke (Peer reviewed; Journal article, 2022)The regulation and monitoring of pharmaceutical pollution in Europe lag behind that of more prominent groups. However, the repurposing of sales data to predict surface water environmental concentrations is a promising ... -
Predicting Environmental Risks of Pharmaceuticals from Wholesale Data: An Example from Norway
Welch, Samuel A.; Moe, S. Jannicke; Sharikabad, Mohammad Nouri; Tollefsen, Knut-Erik; Olsen, Kristine; Grung, Merete (Peer reviewed; Journal article, 2023)Environmental risk assessment (ERA) of pharmaceuticals relies on available measured environmental concentrations, but often such data are sparse. Predicted environmental concentrations (PECs), calculated from sales weights, ... -
Prioritisation of water pollutants: the EU Project SOLUTIONS proposes a methodological framework for the integration of mixture risk assessments into prioritisation procedures under the European Water Framework Directive
Faust, Michael; Backhaus, Thomas; Altenburger, Rolf; Dulio, Valeria; van Gils, Jos; Ginebreda, Antonio; Kortenkamp, Andreas; Munthe, John; Posthuma, Leo; Slobodnik, Jaroslav; Tollefsen, Knut-Erik; van Wezel, Annemarie; Brack, Werner (Journal article; Peer reviewed, 2019)Current prioritisation procedures under the EU Water Framework Directive (WFD) do not account for risks from chemical mixtures. SOLUTIONS proposes a multiple-lines-of-evidence approach to tackle the problem effectively. ... -
Probabilistic risk assessment of pesticides under future agricultural and climate scenarios using a bayesian network
Mentzel, Sophie; Grung, Merete; Holten, Roger; Tollefsen, Knut-Erik; Stenrød, Marianne; Moe, S. Jannicke (Peer reviewed; Journal article, 2022)The use of Bayesian networks (BN) for environmental risk assessment has increased in recent years as they offer a more transparent way to characterize risk and evaluate uncertainty than the traditional risk assessment ... -
Profiling of the embryonic Atlantic halibut (Hippoglossus hippoglossus L.) transcriptome reveals maternal transcripts as potential markers of embryo quality
Mommens, Maren; Fernandes, Jorge; Tollefsen, Knut-Erik; Johnston, Ian A.; Babiak, Igor (Journal article; Peer reviewed, 2014) -
Quantification of an Adverse Outcome Pathway Network by Bayesian Regression and Bayesian Network Modeling
Moe, S. Jannicke; Wolf, Raoul; Xie, Li; Landis, Wayne G.; Kotamäki, Niina; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2020)The adverse outcome pathway (AOP) framework has gained international recognition as a systematic approach linking mechanistic processes to toxicity endpoints. Nevertheless, successful implementation into risk assessments ... -
Repeatability and reproducibility of the RTgill-W1 cell line assay for predicting fish acute toxicity
Fischer, Melanie; Belanger, Scott E.; Berckmans, Pascale; Bernhard, Mary J.; Bláha, Ludek; Coman Schmid, Diana E.; Dyer, Scott D.; Haupt, Tina; Hermens, Joop L.M.; Hultman, Maria Thérése; Laue, Heike; Lillicrap, Adam David; Mlnaříková, Marie; Natsch, Andreas; Novák, Jirí; Sinnige, Theo L.; Tollefsen, Knut-Erik; Niederhäusern, Valentin von; Witters, Hilda; Zupanic, Anze; Schirmer, Kristin (Journal article; Peer reviewed, 2019)Predicting fish acute toxicity of chemicals in vitro is an attractive alternative method to the conventional approach using juvenile and adult fish. The rainbow trout (Oncorhynchus mykiss) cell line assay with RTgill-W1 ... -
A review of quantitative structure-activity relationship modelling approaches to predict the toxicity of mixtures
Belfield, Samuel J.; Firman, James W.; Enoch, Steven J.; Madden, Judith C.; Tollefsen, Knut-Erik; Cronin, Mark T.D. (Peer reviewed; Journal article, 2022)Exposure to chemicals generally occurs in the form of mixtures. However, the great majority of the toxicity data, upon which chemical safety decisions are based, relate only to single compounds. It is currently unfeasible ... -
Susceptibility of polar cod (Boreogadus saida) to a model carcinogen
Lerebours, Adélaïde; Murzina, Svetlana; Song, You; Tollefsen, Knut-Erik; Benedetti, Maura; Regoli, Francesco; Rotchell, Jeanette M.; Nahrgang, Jasmine (Peer reviewed; Journal article, 2021)Studies that aim to characterise the susceptibility of the ecologically relevant and non-model fish polar cod (Boreogadus saida) to model carcinogens are required. Polar cod were exposed under laboratory conditions for six ... -
Transgenic (cyp19a1b-GFP) zebrafish embryos as a tool for assessing combined effects of oestrogenic chemicals
Petersen, Karina; Fetter, Eva; Kah, Olivier; Brion, François; Scholz, Stefan; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2013)Endocrine disrupting chemicals and especially oestrogen receptor (ER) agonists have been extensively studied over the years due to their potential effects on sexual development and reproduction in vertebrates, notably fish. ... -
Ultraviolet B modulates gamma radiation-induced stress responses in Lemna minor at multiple levels of biological organisation
Xie, Li; Song, You; Petersen, Karina; Solhaug, Knut Asbjørn; Lind, Ole Christian; Brede, Dag Anders; Salbu, Brit; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2022)Elevated levels of ionizing and non-ionizing radiation may co-occur and pose cumulative hazards to biota. However, the combined effects and underlying toxicity mechanisms of different types of radiation in aquatic plants ... -
Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses
Scheibener, Shane; Song, You; Tollefsen, Knut-Erik; Salbu, Brit; Teien, Hans-Christian (Peer reviewed; Journal article, 2021)The importance of incorporating kinetic approaches in order to gain information on underlying physiological processes explaining species sensitivity to environmental stressors has been highlighted in recent years. Uranium ... -
Using a Bayesian Network Model to Predict Risk of Pesticides on Aquatic Community Endpoints in a Rice Field—A Southern European Case Study
Mentzel, Sophie; Martínez-Megías, Claudia; Grung, Merete; Rico, Andreu; Tollefsen, Knut-Erik; Van den Brink, Paul J.; Moe, S. Jannicke (Peer reviewed; Journal article, 2023)Bayesian network (BN) models are increasingly used as tools to support probabilistic environmental risk assessments (ERAs), because they can better account for uncertainty compared with the simpler approaches commonly used ...