Browsing NIVA Open Access Archive by Author "Tollefsen, Knut-Erik"
Now showing items 1-20 of 41
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Age and Synchronization of Daphnia magna Affect Sensitivity to Teflubenzuron in Acute Standardized Toxicity Tests
Nordblad Schmidt, Simon; Rundberget, Thomas; Song, You; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2023)The standard Daphnia sp. acute toxicity test for assessing the adverse effects of chemicals on aquatic invertebrates stipulates the use of neonates that are ≤24 h old (hours post release [hpr]) at the start of the exposure. ... -
Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations
Bajard, Lola; Adamovsky, Ondrej; Audouze, Karine; Baken, Kirsten; Barouki, Robert; Beltman, Joost B.; Beronius, Anna; Bonefeld-Jørgensen, Eva Cecilie; Cano-Sancho, German; de Baat, Milo L.; Di Tillio, Filippo; Fernandez, Mariana F.; FitzGerald, Rex E.; Gundacker, Claudia; Hernández, Antonio F.; Hilscherova, Klara; Karakitsios, Spyros; Kuchovska, Eliska; Long, Manhai; Luijten, Mirjam; Majid, Sanah; Marx-Stoelting, Philip; Mustieles, Vicente; Negi, Chander K.; Sarigiannis, Dimosthenis; Scholz, Stefan; Sovadinova, Iva; Stierum, Rob; Tanabe, Shihori; Tollefsen, Knut-Erik; van den Brand, Annick D.; Vogs, Carolina; Wielsøe, Maria; Wittwehr, Clemens; Blaha, Ludek (Peer reviewed; Journal article, 2022)While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate ... -
A Bayesian Approach to Incorporating Spatiotemporal Variation and Uncertainty Limits into Modeling of Predicted Environmental Concentrations from Chemical Monitoring Campaigns
Wolf, Raoul; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2021)Environmental monitoring studies provide key information to assess ecosystem health. Results of chemical monitoring campaigns can be used to identify the exposure scenarios of regulatory concern. In environmental risk ... -
Combined effects of pharmaceuticals, personal care products, biocides and organic contaminants on the growth of Skeletonema pseudocostatum
Petersen, Karina; Heiaas, Harald; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2014)Organisms in the environment are exposed to a number of pollutants from different compound groups. Inaddition to the classic pollutants like the polychlorinated biphenyls, polyaromatic hydrocarbons (PAHs),alkylphenols, ... -
Comparison of piecewise structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network
Cao, Yang; Moe, S. Jannicke; De Bin, Riccardo; Tollefsen, Knut-Erik; Song, You (Peer reviewed; Journal article, 2023)Quantitative adverse outcome pathway network (qAOPN) is gaining momentum due to the predictive nature, alignment with quantitative risk assessment and great potential as a computational new approach methodology (NAM) to ... -
Considerations for application of benchmark dose modeling in radiation research: workshop highlights
Chauhan, Vinita; Yu, Jihang; Vuong, Ngoc; Haber, Lynne T.; Williams, Andrew; Auerbach, Scott S.; Beaton, Danielle; Wang, Yi; Stainforth, Robert; Wilkins, Ruth C.; Azzam, Edouard I.; Richardson, Richard B.; Khan, Md Gulam Musawwir; Jadhav, Ashok; Burtt, Julie J.; Leblanc, Julie; Randhawa, Kristi; Tollefsen, Knut-Erik; Yauk, Carole L. (Peer reviewed; Journal article, 2023)Exposure to different forms of ionizing radiation occurs in diverse occupational, medical, and environmental settings. Improving the accuracy of the estimated health risks associated with exposure is therefore, essential ... -
Development of a Bayesian network for probabilistic risk assessment of pesticides
Mentzel, Sophie; Grung, Merete; Tollefsen, Knut-Erik; Stenrød, Marianne; Petersen, Karina; Moe, S. Jannicke (Peer reviewed; Journal article, 2021)Conventional environmental risk assessment of chemicals is based on a calculated risk quotient, representing the ratio of exposure to effects of the chemical, in combination with assessment factors to account for uncertainty. ... -
Dose-dependent hepatic transcriptional responses in Atlantic salmon (Salmo salar) exposed to sublethal doses of gamma radiation
Song, You; Salbu, Brit; Teien, Hans-Christian; Heier, Lene Sørlie; Rosseland, Bjørn Olav; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2014)Due to the production of free radicals, gamma radiation may pose a hazard to living organisms. The high-dose radiation effects have been extensively studied, whereas the ecotoxicity data on low-dose gamma radiation is still ... -
The ecotoxicology of marine tributyltin (TBT) hotspots: A review
Beyer, Jonny; Song, You; Tollefsen, Knut-Erik; Berge, John Arthur; Tveiten, Lise Ann; Helland, Aud; Øxnevad, Sigurd; Schøyen, Merete (Peer reviewed; Journal article, 2022)Tributyltin (TBT) was widely used as a highly efficient biocide in antifouling paints for ship and boat hulls. Eventually, TBT containing paints became globally banned when TBT was found to cause widespread contamination ... -
Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization
Xie, Li; Solhaug, Knut Asbjørn; Song, You; Johnsen, Bjørn; Olsen, Jorunn Elisabeth; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2020)Macrophytes inhabit waterways around the world and are used in hydroponics or aquaponics for different purposes such as feed and wastewater treatment and are thus exposed to elevated levels of UVB from natural and artificial ... -
Effects of petrogenic pollutants on North Atlantic and Arctic Calanus copepods: From molecular mechanisms to population impacts
Hansen, Bjørn Henrik; Tarrant, Ann M.; Lenz, Petra H.; Roncalli, Vittoria; Almeda, Rodrigo; Broch, Ole Jacob; Altin, Dag; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2023)Oil and gas industries in the Northern Atlantic Ocean have gradually moved closer to the Arctic areas, a process expected to be further facilitated by sea ice withdrawal caused by global warming. Copepods of the genus ... -
Environmental risk assessment of combined effects in aquatic ecotoxicology: A discussion paper
Beyer, Jonny; Petersen, Karina; Song, You; Ruus, Anders; Grung, Merete; Bakke, Torgeir Heggelund; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2014)Environmental regulatory edicts within the EU, such as the regulatory framework for chemicals REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals), the Water Framework Directive (WFD), and the Marine ... -
Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation
Thaulow, Jens; Song, You; Lindeman, Leif C; Kamstra, Jorke H; YeonKyeong, Lee; Xie, Li; Aleström, Peter; Salbu, Brit; Tollefsen, Knut-Erik (Peer reviewed; Journal article, 2020)Ionizing radiation is known to induce oxidative stress and DNA damage as well as epigenetic effects in aquatic organisms. Epigenetic changes can be part of the adaptive responses to protect organisms from radiation-induced ... -
Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-Azacytidine
Lindeman, Leif Christopher; Thaulow, Jens; Song, You; Kamstra, Jorke H; Xie, Li; Asselman, Jana; Alestrøm, Peter; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2019)The water flea Daphnia magna is a keystone species in freshwater ecosystems and has been widely used as a model organism in environmental ecotoxicology. This aquatic crustacean is sensitive to environmental stressors and ... -
Evaluation of the sensitivity, responsiveness and reproducibility of primary rainbow trout hepatocyte vitellogenin expression as a screening assay for estrogen mimics
Hultman, Maria Thérése; Rundberget, Thomas; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2014)Vitellogenin (Vtg) induction in primary fish hepatocytes has been proposed as an in vitro screening assay for ER agonists and antagonists, but has not yet been used extensively as a high-throughput screening tool due to ... -
Exploring BPA alternatives – Environmental levels and toxicity review
Adamovsky, Ondrej; Groh, Ksenia J.; Białk-Bielińska, Anna; Escher, Beate I.; Beaudouin, R.; Mora Lagares, Liadys; Tollefsen, Knut-Erik; Fenske, Martina; Mulkiewicz, Ewa; Creusot, Nicolas; Sosnowska, Anita; Loureiro, Susana; Beyer, Jonny; Repetto, Guillermo; Štern, Alja; Lopes, Isabel; Monteiro, Marta; Zikova-Kloas, Andrea; Eleršek, Tina; Vračko, Marjan; Zdybel, Szymon; Puzyn, Tomasz; Koczur, Weronika; Ebsen Morthorst, Jane; Holbech, Henrik; Carlsson, Gunnar; Örn, Stefan; Herrero, Óscar; Siddique, Ayesha; Liess, Matthias; Braun, Georg; Srebny, Vanessa; Žegura, Bojana; Hinfray, Nathalie; Brion, François; Knapen, Dries; Vandeputte, Ellen; Stinckens, Evelyn; Vergauwen, Lucia; Behrendt, Lars; João Silva, Maria; Blaha, Ludek; Kyriakopoulou, Katerina (Peer reviewed; Journal article, 2024)Bisphenol A alternatives are manufactured as potentially less harmful substitutes of bisphenol A (BPA) that offer similar functionality. These alternatives are already in the market, entering the environment and thus raising ... -
Exposure and toxicity of mixtures of plant protection products (PPPs) in the environment under Norwegian conditions. Evaluation of a cumulative environmental risk assessment of PPPs
Petersen, Karina; Stenrød, Marianne; Odenmarck, Sven Roar; Fredriksen, Lene; Gomes, Tania; Backhaus, Thomas; Tollefsen, Knut-Erik (NIVA-rapport;6830, Research report, 2015)This project was performed to improve the environmental cumulative risk assessment (CRA) of mixtures of plant protection products detected by the Norwegian Agricultural Environmental Monitoring Programme (JOVA) in Norwegian ... -
Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium
Song, You; Salbu, Brit; Teien, Hans-Christian; Heier, Lene Sørlie; Rosseland, Bjørn Olav; Høgåsen, Tore; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2014)Potential environmental hazards of radionuclides are often studied at the individual level. Sufficient toxicogenomics data at the molecular/cellular level for understanding the effects and modes of toxic action (MoAs) of ... -
Hepatic transcriptomic profiling reveals early toxicological mechanisms of uranium in Atlantic salmon (Salmo salar)
Song, You; Salbu, Brit; Teien, Hans-Christian; Heier, Lene Sørlie; Rosseland, Bjørn Olav; Høgåsen, Tore; Tollefsen, Knut-Erik (Journal article; Peer reviewed, 2014) -
In silico identification of chemicals capable of binding to the ecdysone receptor
Mellor, Claire L.; Tollefsen, Knut-Erik; LaLone, Carlie; Cronin, Mark T.D.; Firman, James W. (Peer reviewed; Journal article, 2020)The process of molting, known alternatively as ecdysis, is a feature integral in the life cycles of species across the arthropod phylum. Regulation occurs as a function of the interaction of ecdysteroid hormones with the ...