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dc.contributor.authorOtt, Amelie
dc.contributor.authorMartin, Timothy J.
dc.contributor.authorAcharya, Kishor
dc.contributor.authorLyon, Delina Y.
dc.contributor.authorRobinson, Nik
dc.contributor.authorRowles, Bob
dc.contributor.authorSnape, Jason R.
dc.contributor.authorStill, Ian
dc.contributor.authorWhale, Graham F.
dc.contributor.authorAlbright, Vurtice C.
dc.contributor.authorBäverbäck, Petra
dc.contributor.authorBest, Nicola
dc.contributor.authorCommander, Ruth
dc.contributor.authorEickhoff, Curtis
dc.contributor.authorFinn, Sarah
dc.contributor.authorHidding, Björn
dc.contributor.authorMaischak, Heiko
dc.contributor.authorSowders, Katherine A.
dc.contributor.authorTaruki, Masanori
dc.contributor.authorWalton, Helen E.
dc.contributor.authorWennberg, Aina Charlotte
dc.contributor.authorDavenport, Russell J.
dc.date.accessioned2020-10-27T15:22:11Z
dc.date.available2020-10-27T15:22:11Z
dc.date.created2020-09-06T21:15:15Z
dc.date.issued2020
dc.identifier.citationEnvironmental Science and Technology. 2020, 54 (7), 4210-4220.en_US
dc.identifier.issn0013-936X
dc.identifier.urihttps://hdl.handle.net/11250/2685359
dc.descriptionEmbargo until 12 March 2021en_US
dc.description.abstractCurrent biodegradation screening tests are not specifically designed for persistence assessment of chemicals, often show high inter- and intra-test variability, and often give false negative biodegradation results. Based on previous studies and recommendations, an international ring test involving 13 laboratories validated a new test method for marine biodegradation with a focus on improving the reliability of screening to determine the environmental degradation potential of chemicals. The new method incorporated increased bacterial cell concentrations to better represent the microbial diversity; a chemical is likely to be exposed in the sampled environments and ran beyond 60 days, which is the half-life threshold for chemical persistence in the marine environment. The new test provided a more reliable and less variable characterization of the biodegradation behavior of five reference chemicals (sodium benzoate, triethanolamine, 4-nitrophenol, anionic polyacrylamide, and pentachlorophenol), with respect to REACH and OSPAR persistence thresholds, than the current OECD 306 test. The proposed new method provides a cost-effective screening test for non-persistence that could streamline chemical regulation and reduce the cost and animal welfare implications of further higher tier testing.en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.titleMulti-laboratory validation of a new marine biodegradation screening test for chemical persistence assessmenten_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionacceptedVersionen_US
dc.source.pagenumber4210-4220en_US
dc.source.volume54en_US
dc.source.journalEnvironmental Science and Technologyen_US
dc.source.issue7en_US
dc.identifier.doi10.1021/acs.est.9b07710
dc.identifier.cristin1827589
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


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